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Muscular dystrophy

Muscular dystrophy refers to a group of genetic, hereditary muscle diseases that cause progressive muscle weakness. Muscular dystrophies are characterised by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue.

For more information: http://www.animalresearch.info/en/medical-advances/diseases-research/muscular-dystrophy/

 

16/11/15 potential treatment for Duchenne Muscular dystrophy in dogs

The Royal Veterinary college is conducting work in beagles to understand the progression, and find potential treatments, for Duchenne Muscular Dystrophy - a muscle wasting disease. The disease affects around 2,500 boys in the UK - resulting in most being wheelchair bound by the age of 12. The researchers are using MRIs to study the action of the heart of the DMD dogs

http://www.theguardian.com/science/2015/nov/15/beagles-study-hope-cure-muscular-dystrophy

28/11/14 Duchenne muscular dystrophy mutation corrected using genome editing

Nobel Laureate Shinya Yamanaka has shown that genetic mutations that cause Duchenne muscular dystrophy can be corrected using genome editing. Muscular dystrophy is a degenerative disease caused by a defect in a gene that makes dystrophin protein. Without dystrophin muscle fibres become damaged and waste away. Even though there is no hope to correct all the defective genes in a patient’s body, injections of healthy cells could provide enough dystrophin to boost their existing muscle tissue. 

http://www.theguardian.com/science/2014/nov/26/muscular-dystrophy-therapy-breakthrough
 


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