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Heart disorders

This describes many different conditions affecting the heart. Approximately 600,000 people die from heart disease in the United States every year, according to the CDC. It’s a leading cause of death in both men and women.

 

19/01/17 Robotic sleeve 'hugs' failing hearts

Scientists have developed a robotic sleeve that can help hearts pump when they are failing. The sleeve - made of material that mimics heart muscle - hugs the outside of the heart and squeezes it, mimicking the action of cardiac muscle. The early study, published in Science Translational Medicine, shows the concept works on pig hearts. The British Heart Foundation describes it as a "novel approach" that requires further trials.

http://www.bbc.co.uk/news/health-38651596

http://www.sciencemag.org/news/2017/01/heart-hugging-device-could-help-keep-beat

06/05/16 Drug rampamycin can improve the heart functionality of dogs

Scientists at the University of Washington have found a drug, rampamycin, can improve the heart functionality of dogs. In mice it has been found to extend their lives by 13%. It is currently unknown what the effects on human life expectancy would be. "Rapamycin is already used in transplant patients to prevent organ rejection and several years ago, and scientists in the journal Neuroscience said it can improve learning and help treat cognitive decline."

http://www.dailymail.co.uk/…/Could-miracle-drug-extend-life…

20/08/15 Good cholesterol gets even better

The molecule that removes cholesterol from arteries could have another protective effect in heart disease: curbing inflammation. High-density lipoprotein (HDL; known as the 'good cholesterol') transports fat from blood-vessel walls to the liver for excretion. But it also carries the fatty signalling molecule S1P, which activates the anti-inflammatory receptor S1P1.

doi:10.1038/524269c http://stke.sciencemag.org/content/8/389/ra79

11/06/15 Heartburn drug could increase heart attack risk

Heartburn drug could increase heart attack risk. Proton pump inhibitors (PPI) are one of the commonly prescribed drugs – around 8 million prescriptions in the UK each year plus over the counter sales - but it increases by 16-21% the risk of heart attacks. However, the study could not definitively prove the drugs were causing the heart attacks; it could be that the patients taking the drugs are simply sicker and more likely to get a heart attack. PPI drugs work by blocking the actions of cells called proton pumps, which produce stomach acid and animal studies and cell cultures showed that PPIs led to a drop in the level of nitric oxide, causing vessels to narrow and inflame.

http://www.theguardian.com/society/2015/jun/09/heartburn-drugs-could-increase-heart-attack-risk-scientists

20/05/15 stem cell injection improves heart function in mice

Researchers from Imperial College London showed that an injection of stem cells into a mouse with heart damage showed improved heart function, despite most of the donor cells not remaining in the heart. Researchers will now be interested to find out if humans have similar heart stem cells that act in a similar way.

 

http://www.nhs.uk/…/Stem-cells-could-provide-a-treatment%20…

07/04/15 Heart muscle cells regrown, thanks to research in mice

Heart muscle cells regrown in medical breakthrough, thanks to research in mice. Unlike salamanders, humans cannot regenerate parts of their bodies when they get damaged – making heart attacks hard to recover form. But scientists have discovered a way to stimulate heart muscle cells to multiply in mice – the stimulation of a signalling system driven by the hormone neuregulin in the heart allowed the heart muscle cells to divide once again. Triggering the neuregulin pathway following a heart attack in the mice lead to replacement of lost muscle, restoring the heart.

03/11/14 Surgical device for heart defects in children successfully trialled in pigs

A tiny surgical device that could be used to treat a heart defect in children has been successfully trialed in pigs. The device is a long flexible tube with cutting teeth at the end that is inserted through the neck into the jugular vein and passed into the heart to cut a small hole in the wall between the two upper chambers. Surgeons use external ultrasound images to guide it to the heart, and switched on the cutting teeth remotely. Currently many operations of this kind require cutting open a child’s chest and ribs to access the heart.

http://www.newscientist.com/article/mg22429935.100-heart-ops-shrink-thanks-to-surgeon-in-your-vein.html#.VFdiEfmsVRp 


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